Deep nasolabial folds can be effectively treated using PDO threads that are placed along and beneath the fold lines to provide structural support from within. Unlike dermal fillers that simply add volume, PDO threads create a scaffolding effect that lifts the surrounding tissue and stimulates new collagen production, providing more natural, longer-lasting improvement. The threads gradually dissolve over several months, but the collagen they stimulate remains, continuing to provide support and smoothing of the folds. This treatment is particularly effective for deeper folds that may not respond adequately to filler alone, and can be combined with filler for a comprehensive approach to nasolabial fold reduction.